Fenticonazole Nitrate

Generic Name

Fenticonazole-nitrate

Other Names

• Fenticetin
• Gynoxin

Drug Class

• Antifungal

Chemical Formula

C24H21Cl2N3O5

Molecular Weight

503.34 g/mol

Mechanism of Action

• Inhibits fungal ergosterol synthesis

Indications

• Vaginal yeast infections
• Dermatophytosis
• Cutaneous fungal infections

Common Dosage Forms

• Vaginal cream
• Vaginal suppositories

Typical Dosage

• Vaginal cream: Apply a thin layer once daily for 7 days
• Vaginal suppositories: Insert one suppository daily for 3 days

Pediatric Dosage

• Safety and efficacy not established in children

Geriatric Dosage

• Dose adjustment may be required in elderly patients

Side Effects

• Local irritation
• Erythema
• Burning sensation

Contraindications

• Hypersensitivity to fenticonazole or any component of the formulation

Pregnancy Category

• Category C - Animal reproduction studies have shown an adverse effect on the fetus

Lactation Safety

• Limited data available, caution advised

Drug Interactions

• No significant drug interactions reported

Overdose Symptoms

• Not well documented

Antidote for Overdose

• No specific antidote

Storage Conditions

• Store at room temperature away from moisture and heat

Pharmacokinetics

• Absorption: Well absorbed after topical administration
• Distribution: Limited information available
• Metabolism: Metabolized in the liver
• Excretion: Excreted in urine and feces

Precautions

• Avoid contact with eyes
• Not for oral use
• Use with caution in patients with hepatic impairment

Warnings

• For topical use only
• Consult healthcare provider if symptoms do not improve after treatment

Others

• Do not use tampons, douches, spermicides, or other vaginal products during treatment