Fluocinolone Acetonide + Hydroquinone + Tretinoin
Generic Details
Generic Name
Fluocinolone Acetonide + Hydroquinone + Tretinoin
Other Names
- Fluocinolone Acetonide/Hydroquinone/Tretinoin
- Triple Combination Cream
Drug Class
- Topical Corticosteroid
- Skin-Lightening Agent
- Topical Retinoid
Chemical Formula
Molecular Weight
Mechanism of Action
- Fluocinolone Acetonide: anti-inflammatory and immunosuppressive effects
- Hydroquinone: inhibits melanin production
- Tretinoin: promotes skin cell turnover and exfoliation
Indications
- Melasma
- Hyperpigmentation
- Acne scars
- Skin discoloration
Common Dosage Forms
- Cream
- Gel
Typical Dosage
- Apply a thin layer to the affected area once daily in the evening
Pediatric Dosage
- Safety and efficacy not established in children
Geriatric Dosage
- Use with caution and consult healthcare provider
Side Effects
- Skin irritation
- Redness
- Dryness
- Peeling
- Burning sensation
Contraindications
- Hypersensitivity to any component
- Pregnancy
- Children under 12 years
Pregnancy Category
- Category C - Consult healthcare provider before use
Lactation Safety
- Safety not established - Consult healthcare provider before use
Drug Interactions
- Inform healthcare provider about all medications used concurrently
Overdose Symptoms
- Excessive skin irritation
- Increased risk of side effects
Antidote for Overdose
- Discontinue use and seek medical attention
Storage Conditions
- Store at room temperature (15-30°C)
- Protect from light and moisture
Pharmacokinetics
- Absorption: Topical application - Limited systemic absorption
- Distribution: Not well studied
- Metabolism: Hepatic
- Excretion: Mainly renal
Precautions
- Avoid contact with eyes, lips, and mucous membranes
- Use sun protection during treatment
- Do not apply to broken or irritated skin
Warnings
- For external use only
- Not for ophthalmic use
- Avoid prolonged use without medical supervision
Others
- Regular follow-up with healthcare provider is recommended for monitoring progress