Fluocinolone Acetonide
Generic Details
Generic Name
Fluocinolone Acetonide
Other Names
- Derma-Smoothe/FS
- Fluonid
- Capex
- Synalar
Drug Class
- Corticosteroid
Chemical Formula
C24H30F2O6
Molecular Weight
452.49 g/mol
Mechanism of Action
- Fluocinolone acetonide exerts anti-inflammatory, antipruritic, and vasoconstrictive actions.
Indications
- Atopic dermatitis
- Psoriasis
- Contact dermatitis
- Seborrheic dermatitis
- Allergic reactions
- Eczema
Common Dosage Forms
- Cream
- Ointment
- Topical Solution
- Scalp Oil
Typical Dosage
- Apply a thin layer to the affected skin 2-4 times daily
Pediatric Dosage
- Dosage adjustment may be needed based on age and condition
Geriatric Dosage
- Dosage adjustment may be needed based on age and condition
Side Effects
- Skin irritation
- Burning
- Itching
- Dryness
- Acne
- Folliculitis
Contraindications
- Hypersensitivity to fluocinolone acetonide or any component of the formulation
Pregnancy Category
- Category C - Animal reproduction studies have shown an adverse effect on the fetus
Lactation Safety
- Use with caution during breastfeeding
Drug Interactions
- No significant drug interactions reported
Overdose Symptoms
- Excessive topical use may lead to systemic effects such as Cushing's syndrome
Antidote for Overdose
- Discontinue medication and provide symptomatic treatment
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Topical application leads to systemic absorption in varying amounts
- Distribution: Distributed widely in the body tissues
- Metabolism: Metabolized in the liver
- Excretion: Excreted mainly in the urine
Precautions
- Avoid use on broken or infected skin
- Not for long-term use on large areas of the body
Warnings
- Prolonged use may lead to skin thinning and systemic effects