Fluorescein Sodium

Generic Details

Generic Name

Fluorescein sodium

Other Names

  • Fluorescein

Drug Class

  • Diagnostic agent

Chemical Formula

C20H10Na2O5

Molecular Weight

376.27 g/mol

Mechanism of Action

  • Fluorescein sodium is a fluorescent dye that selectively accumulates in the cornea, producing a bright yellow-green discoloration under blue light. It is used in ophthalmic examinations to visualize and evaluate the integrity of the corneal surface.

Indications

  • Ophthalmic angiography
  • Corneal abrasion detection
  • Contact lens fitting
  • Assessment of tear drainage

Common Dosage Forms

  • Ophthalmic solution

Typical Dosage

  • 1-2 drops of 2% solution instilled into the eye(s)

Pediatric Dosage

  • As directed by a healthcare provider

Geriatric Dosage

  • As directed by a healthcare provider

Side Effects

  • Transient blurring of vision
  • Stinging or discomfort upon instillation
  • Conjunctival injection (redness of the eye)

Contraindications

  • Hypersensitivity to fluorescein sodium
  • History of allergic reactions to fluorescein or related compounds

Pregnancy Category

  • C - Consult a healthcare provider for risks and benefits

Lactation Safety

  • Compatible with breastfeeding as minimal systemic absorption

Drug Interactions

  • No significant drug interactions reported

Overdose Symptoms

  • Excessive tearing
  • Increased lacrimation
  • Mild ocular discomfort

Antidote for Overdose

  • Rinse the eyes with sterile saline or water

Storage Conditions

  • Store at room temperature (15-30°C)
  • Protect from light

Pharmacokinetics

  • Absorption: Rapidly absorbed through the cornea
  • Distribution: Localizes in the cornea and is minimally distributed systemically
  • Metabolism: Metabolized in the liver
  • Excretion: Excreted mainly in the urine

Precautions

  • Use with caution in patients with known allergies to fluorescein or related compounds
  • Avoid contact with soft contact lenses

Warnings

  • Not for injection
  • Do not use if solution changes color or becomes cloudy

Others

  • For ophthalmic use only
  • Discard unused portion of the solution after single-use