Flupentixol Dihydrochloride
Generic Details
Generic Name
Flupentixol
Other Names
- Flupenthixol
Drug Class
- Antipsychotic
Chemical Formula
C23H27F3N2O2S
Molecular Weight
448.54 g/mol
Mechanism of Action
- Dopamine D2 receptor antagonist
Indications
- Schizophrenia
- Bipolar disorder
- Depression with psychotic features
Common Dosage Forms
- Tablet
- Solution for injection
Typical Dosage
- 5-20 mg/day orally in divided doses
Pediatric Dosage
- Safety and efficacy not established in children
Geriatric Dosage
- Caution advised; start with lower doses
Side Effects
- Sedation
- Extrapyramidal symptoms
- Weight gain
- Hyperprolactinemia
- Orthostatic hypotension
Contraindications
- Hypersensitivity to flupentixol
- Coma
- CNS depression
Pregnancy Category
- C - Risk cannot be ruled out
Lactation Safety
- Use with caution; excretion in breast milk reported
Drug Interactions
- Avoid with other medications causing CNS depression or anticholinergic effects
Overdose Symptoms
- Severe extrapyramidal symptoms
- Cardiac effects
Antidote for Overdose
- Supportive care and symptomatic treatment
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed after oral administration
- Distribution: Highly distributed in tissues
- Metabolism: Metabolized in the liver via CYP2D6
- Excretion: Primarily excreted in urine and feces
Precautions
- Caution in elderly patients
- Monitor for changes in mood or behavior
Warnings
- May cause drowsiness; avoid driving or operating machinery