Flupentixol + Melitracen
Generic Details
Generic Name
Flupentixol-Melitracen
Other Names
- Fluanxol
- Deanxit
Drug Class
- Antipsychotic
- Antidepressant
Chemical Formula
Molecular Weight
Mechanism of Action
- Flupentixol: Dopamine D2 receptor antagonist
- Melitracen: Tricyclic antidepressant (TCA), inhibits serotonin and norepinephrine reuptake
Indications
- Major depressive disorder (MDD)
- Anxiety disorders
- Schizophrenia
- Bipolar disorder
- Neuropathic pain
Common Dosage Forms
- Tablet
- Capsule
Typical Dosage
- Flupentixol-Melitracen 0.5/10 mg once daily
Pediatric Dosage
Geriatric Dosage
Side Effects
- Drowsiness
- Dry mouth
- Constipation
- Weight gain
- Extrapyramidal effects (tremor, rigidity)
- Orthostatic hypotension
Contraindications
- Hypersensitivity to Flupentixol or Melitracen
- Severe hepatic impairment
- Angle-closure glaucoma
Pregnancy Category
- Category C - Risk cannot be ruled out
Lactation Safety
- Use with caution; pass into breast milk
Drug Interactions
- MAO inhibitors
- Tricyclic antidepressants
- Benzodiazepines
Overdose Symptoms
- Seizures
- Cardiac arrhythmias
- Severe hypotension
Antidote for Overdose
- No specific antidote; symptomatic and supportive treatment
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed orally
- Distribution: Highly bound to plasma proteins
- Metabolism: Extensively hepatic via CYP enzymes
- Excretion: Mainly renal excretion
Precautions
- Caution in patients with cardiovascular diseases
- Close monitoring in elderly patients
Warnings
- May increase the risk of suicidal thoughts in patients under 25
- May cause QT interval prolongation