Furosemide

Generic Details

Generic Name

Furosemide

Other Names

Lasix

Drug Class

Loop diuretic

Chemical Formula

C12H11ClN2O5S

Molecular Weight

330.74 g/mol

Mechanism of Action

Inhibits the reabsorption of sodium and chloride in the ascending loop of Henle in the kidneys, leading to increased diuresis

Indications

Edema due to heart failure, cirrhosis, or kidney disease
Hypertension

Common Dosage Forms

Tablet
Injection
Oral solution

Typical Dosage

20-80 mg per day, orally
IV doses may vary

Pediatric Dosage

1-2 mg/kg/dose orally or IV every 6-8 hours

Geriatric Dosage

Lower initial doses to account for decreased renal function

Side Effects

Hypotension
Electrolyte imbalances (e.g., hypokalemia)
Dehydration
Ototoxicity

Contraindications

Anuria
Hypersensitivity to sulfa drugs

Pregnancy Category

C - Risk cannot be ruled out

Lactation Safety

Compatible with breastfeeding

Drug Interactions

Digoxin
Aminoglycoside antibiotics
NSAIDs

Overdose Symptoms

Severe dehydration
Hypotension
Electrolyte imbalances

Antidote for Overdose

Fluid replacement therapy

Storage Conditions

Store at room temperature away from moisture and heat

Pharmacokinetics

Absorption: Rapidly absorbed from the gastrointestinal tract
Distribution: Widely distributed in the body
Metabolism: Minimal hepatic metabolism
Excretion: Primarily excreted unchanged in the urine

Precautions

Monitor electrolytes and renal function regularly

Warnings

Avoid rapid IV administration to prevent ototoxicity

Others

May be used for acute pulmonary edema