Furosemide + Spironolactone
Generic Details
Generic Name
Furosemide-Spironolactone
Other Names
- Furosemide and Spironolactone combination
Drug Class
- Diuretic combination
Chemical Formula
Molecular Weight
Mechanism of Action
- Furosemide - loop diuretic inhibiting sodium and chloride reabsorption in the ascending loop of Henle
- Spironolactone - potassium-sparing diuretic antagonizing aldosterone
Indications
- Management of fluid retention and edema in conditions such as congestive heart failure
- Hypertension that is uncontrolled with monotherapy
Common Dosage Forms
- Tablet
Typical Dosage
- Initial dose: furosemide 20-40 mg/spironolactone 50 mg once daily
- Adjust dosage based on response
- Maximum dose: furosemide 160 mg/spironolactone 400 mg daily
Pediatric Dosage
- Not established
Geriatric Dosage
- Dosage adjustment may be needed based on renal function
Side Effects
- Electrolyte imbalance (hypokalemia, hyperkalemia)
- Dehydration
- Dizziness
- Muscle cramps
- Fatigue
Contraindications
- Anuria
- Hypersensitivity to sulfonamides
- Severe renal failure
- Hyperkalemia
Pregnancy Category
- C - Discuss risks and benefits with a healthcare provider
Lactation Safety
- Caution advised, excreted into human milk
Drug Interactions
- NSAIDs may reduce diuretic and antihypertensive effects
- ACE inhibitors may increase risk of hyperkalemia
Overdose Symptoms
- Electrolyte disturbances
- Dehydration
- Hypotension
Antidote for Overdose
- Symptomatic treatment and electrolyte repletion
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well-absorbed orally
- Distribution: Both drugs cross the placenta and are excreted in breast milk
- Metabolism: Furosemide - hepatic
- Excretion: Furosemide - renal, Spironolactone - renal
Precautions
- Monitor electrolytes and renal function regularly
- Avoid abrupt withdrawal
- Caution in hepatic impairment
Warnings
- Hyperkalemia risk with concomitant ACE Inhibitor or ARB use