Gabapentin
Generic Details
Generic Name
Gabapentin
Other Names
- Neurontin
- Gralise
- Horizant
Drug Class
- Anticonvulsant
- Neuropathic Pain Agent
Chemical Formula
C9H17NO2
Molecular Weight
171.24 g/mol
Mechanism of Action
- Inhibition of excitatory neurotransmitter release
Indications
- Epilepsy
- Neuropathic pain
- Restless legs syndrome
- Anxiety disorders
Common Dosage Forms
- Capsules
- Tablets
- Oral solution
Typical Dosage
- 300mg to 3600mg per day in divided doses
Pediatric Dosage
- Dosage based on weight and age
Geriatric Dosage
- Lower starting dose may be required
Side Effects
- Dizziness
- Drowsiness
- Weight gain
- Peripheral edema
Contraindications
- Hypersensitivity to gabapentin
Pregnancy Category
- C - Risk cannot be ruled out
Lactation Safety
- Limited data available, caution advised
Drug Interactions
- Alcohol
- Opioids
- Antacids
Overdose Symptoms
- Ataxia
- Drowsiness
- Respiratory depression
Antidote for Overdose
- Supportive care
Storage Conditions
- Store at room temperature away from light and moisture
Pharmacokinetics
- Absorption: Not affected by food
- Distribution: Crosses blood-brain barrier
- Metabolism: Minimal hepatic metabolism
- Excretion: Renal excretion of unchanged drug
Precautions
- Monitor for signs of suicidal thoughts or behavior
Warnings
- May cause dizziness and drowsiness, caution while driving or operating machinery