Gatifloxacin

Generic Details

Generic Name

Gatifloxacin

Other Names

  • Tequin

Drug Class

  • Fluoroquinolone antibiotic

Chemical Formula

C19H21F2N3O3

Molecular Weight

375.39 g/mol

Mechanism of Action

  • Inhibits bacterial DNA gyrase and topoisomerase IV enzymes

Indications

  • Respiratory tract infections
  • Urinary tract infections
  • Skin and soft tissue infections

Common Dosage Forms

  • Tablet
  • Solution for injection

Typical Dosage

  • 400 mg once daily for most indications

Pediatric Dosage

  • Safety and efficacy not established in children under 18 years

Geriatric Dosage

  • Dose adjustment may be required based on renal function

Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Dizziness
  • Headache
  • Photosensitivity

Contraindications

  • Hypersensitivity to gatifloxacin or other quinolones
  • History of tendon disorders related to quinolone use

Pregnancy Category

  • C - Risk cannot be ruled out

Lactation Safety

  • Use with caution, limited human data available

Drug Interactions

  • Avoid concomitant use with Class IA or Class III antiarrhythmic drugs

Overdose Symptoms

  • Risk of CNS stimulation such as seizures

Antidote for Overdose

  • No specific antidote, manage symptoms and provide supportive care

Storage Conditions

  • Store at room temperature away from moisture and heat

Pharmacokinetics

  • Absorption: Well absorbed orally
  • Distribution: Distributed widely in tissues
  • Metabolism: Metabolized in the liver
  • Excretion: Excreted mainly in urine and feces

Precautions

  • Monitor for signs of tendonitis and tendon rupture
  • Caution in patients with known or suspected CNS disorders

Warnings

  • May cause QT prolongation and photosensitivity reactions
  • Avoid in patients with known history of myasthenia gravis

Others

  • Patients should be advised to drink plenty of fluids while using gatifloxacin to prevent crystalluria.