Glibenclamide
Generic Details
Generic Name
Glibenclamide
Other Names
- Glyburide
Drug Class
- Sulfonylurea
Chemical Formula
C23H28ClN3O5S
Molecular Weight
494.01 g/mol
Mechanism of Action
- Stimulates insulin release from pancreatic beta cells
Indications
- Type 2 Diabetes Mellitus
Common Dosage Forms
- Tablet
Typical Dosage
- 2.5-10 mg daily
Pediatric Dosage
- Not recommended for use in children
Geriatric Dosage
- Lower starting doses may be required in elderly patients
Side Effects
- Hypoglycemia
- Nausea
- Diarrhea
- Skin rash
Contraindications
- Type 1 Diabetes Mellitus
- Diabetic Ketoacidosis
- Severe Renal or Hepatic Impairment
Pregnancy Category
- C - Risk cannot be ruled out
Lactation Safety
- Not recommended during breastfeeding
Drug Interactions
- NSAIDs
- Sulfonamides
- Beta-blockers
Overdose Symptoms
- Hypoglycemia
- Seizures
- Coma
Antidote for Overdose
- Glucose
- Diazoxide
- Octreotide
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well-absorbed from the gastrointestinal tract
- Distribution: Protein-bound, distributed mainly in plasma
- Metabolism: Primarily hepatic metabolism
- Excretion: Renal excretion of metabolites
Precautions
- Monitor blood glucose levels regularly
- Caution in patients with sulfa allergy
Warnings
- Risk of hypoglycemia
- Not for the treatment of type 1 diabetes