Glycerin
Generic Details
Generic Name
Glycerin
Other Names
- Glycerol
Drug Class
- Osmotic laxative
Chemical Formula
C3H8O3
Molecular Weight
92.09 g/mol
Mechanism of Action
- Glycerin attracts water into the intestines, softening stool and promoting bowel movements.
Indications
- Constipation
- Dry skin conditions
Common Dosage Forms
- Oral solution
- Topical cream
- Suppositories
Typical Dosage
- Oral: 15-30 ml once daily
- Topical: Apply a thin layer to affected area as needed
- Suppositories: 1 suppository rectally as needed
Pediatric Dosage
- Oral: Consult pediatrician
- Topical: Apply sparingly
Geriatric Dosage
- Dose reduction may be needed due to decreased hepatic or renal function
Side Effects
- Abdominal cramping
- Diarrhea
- Nausea
- Skin irritation (topical use)
Contraindications
- Hypersensitivity to glycerin
- Severe dehydration
- Intestinal blockage
Pregnancy Category
- Category C - consult healthcare provider before use
Lactation Safety
- Considered safe when used as directed
Drug Interactions
- No significant drug interactions reported
Overdose Symptoms
- Severe diarrhea
- Dehydration
Antidote for Overdose
- Discontinue use and treat symptoms
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Glycerin is minimally absorbed orally.
- Distribution: Widely distributed in the body.
- Metabolism: Metabolized in the liver.
- Excretion: Excreted mainly in urine.
Precautions
- Use with caution in patients with kidney disease
- Avoid prolonged use for constipation
Warnings
- Do not use glycerin for more than 1 week without consulting healthcare provider.
Others
- Glycerin is also used as a moisturizing agent in various cosmetic and personal care products.