Griseofulvin [Microsize]

Generic Name

Griseofulvin-microsize

Other Names

• Grifulvin V

Drug Class

• Antifungal agent

Chemical Formula

C17H17ClO6

Molecular Weight

352.77 g/mol

Mechanism of Action

• Inhibits fungal cell mitosis by disrupting microtubule formation

Indications

• Treatment of dermatophyte infections such as tinea capitis, tinea corporis, tinea pedis

Common Dosage Forms

• Tablet
• Oral suspension

Typical Dosage

• 125-500mg once daily or in divided doses

Pediatric Dosage

• Dosing based on body weight

Geriatric Dosage

• Dosage adjustment may be required in renal impairment

Side Effects

• Headache
• Nausea
• Diarrhea
• Rash
• Photosensitivity

Contraindications

• Porphyria

Pregnancy Category

• C

Lactation Safety

• Drug excreted in breast milk, caution advised

Drug Interactions

• Oral contraceptives
• Warfarin
• Cyclosporine

Overdose Symptoms

• Nausea
• Vomiting
• Confusion

Antidote for Overdose

• Supportive care

Storage Conditions

• Store at room temperature away from moisture and heat

Pharmacokinetics

• Absorption: Poorly absorbed from the gastrointestinal tract
• Distribution: Wide distribution in tissues
• Metabolism: Hepatic metabolism
• Excretion: Excreted in urine and feces

Precautions

• Hepatic impairment
• Renal impairment

Warnings

• Increased risk of hepatotoxicity
• May interfere with oral contraceptives

Others

• May take several weeks for full effect to be seen