Pseudoephedrine + Guaiphenasine + Triprolidine

Generic Details

Generic Name

Pseudoephedrine-Guaifenesin-Triprolidine

Other Names

  • Pseudoephedrine-Guaifenesin-Triprolidine Combination

Drug Class

  • Decongestant
  • Expectorant
  • Antihistamine

Chemical Formula

Molecular Weight

Mechanism of Action

  • Pseudoephedrine acts as a nasal decongestant by vasoconstriction.
  • Guaifenesin is an expectorant that promotes mucus clearance.
  • Triprolidine is an antihistamine that alleviates allergy symptoms.

Indications

  • Nasal congestion
  • Cough
  • Allergic rhinitis

Common Dosage Forms

  • Tablets
  • Syrup

Typical Dosage

  • Pseudoephedrine 60mg-Guaifenesin 400mg-Triprolidine 2.5mg every 4-6 hours as needed

Pediatric Dosage

  • Dosage based on weight and age. Consult a healthcare provider.

Geriatric Dosage

  • Lower starting doses may be recommended for the elderly.

Side Effects

  • Dizziness
  • Drowsiness
  • Dry mouth
  • Nausea
  • Headache

Contraindications

  • Hypersensitivity to any component
  • Severe hypertension
  • Severe coronary artery disease

Pregnancy Category

  • Category C - Risk cannot be ruled out

Lactation Safety

  • Caution advised. Limited data available.

Drug Interactions

  • Monoamine oxidase inhibitors (MAOIs)
  • Central nervous system depressants
  • Anticholinergic medications

Overdose Symptoms

  • Agitation
  • Hallucinations
  • Seizures
  • Cardiac arrhythmias

Antidote for Overdose

  • Supportive care with close monitoring. Consider activated charcoal.

Storage Conditions

  • Store at room temperature away from moisture and heat.

Pharmacokinetics

  • Absorption: Rapidly absorbed from the gastrointestinal tract
  • Distribution: Pseudoephedrine widely distributed, Triprolidine and Guaifenesin moderately distributed
  • Metabolism: Hepatic metabolism
  • Excretion: Primarily renal excretion

Precautions

  • Use with caution in patients with hypertension
  • May cause CNS depression
  • Avoid in patients with glaucoma

Warnings

  • May cause drowsiness. Avoid driving or operating machinery until effects are known

Others

  • Avoid alcohol consumption while taking this medication.