Homatropine Hydrobromide

Generic Details

Generic Name

homatropine-hydrobromide

Other Names

  • Homatropine

Drug Class

  • Anticholinergic

Chemical Formula

C16H21NO3.HBr

Molecular Weight

356.25 g/mol

Mechanism of Action

  • Blocks muscarinic acetylcholine receptors

Indications

  • Used as a cycloplegic agent for ophthalmic examinations
  • May also be used to treat uveitis or iritis

Common Dosage Forms

  • Ophthalmic solution

Typical Dosage

  • 1-2 drops in the affected eye(s) every 3-4 hours

Pediatric Dosage

  • Consult pediatric ophthalmologist for appropriate dose

Geriatric Dosage

  • May require lower doses due to increased risk of side effects

Side Effects

  • Blurred vision
  • Stinging or burning in the eyes
  • Increased intraocular pressure
  • Headache

Contraindications

  • Narrow-angle glaucoma
  • Hypersensitivity to anticholinergics

Pregnancy Category

  • C - Use with caution

Lactation Safety

  • May excrete into breast milk, consult healthcare provider

Drug Interactions

  • May potentiate effects of other anticholinergic drugs

Overdose Symptoms

  • Severe dry mouth
  • Hyperthermia
  • Delirium

Antidote for Overdose

  • Physostigmine

Storage Conditions

  • Store at room temperature away from light and moisture

Pharmacokinetics

  • Absorption: Absorbed systemically after ophthalmic administration
  • Distribution: Unknown
  • Metabolism: Hepatic
  • Excretion: Renal

Precautions

  • Caution in patients with narrow angles or predisposition to angle-closure glaucoma

Warnings

  • Do not use in patients with narrow-angle glaucoma

Others

  • Should be used under the supervision of an ophthalmologist