Gramacidin + Neomycin + Polymixin B
Generic Details
Generic Name
Gramacidin-Neomycin-Polymixin-B
Other Names
- G.N.P. Ointment
- Triple Antibiotic Ointment
Drug Class
- Topical Antibacterial
Chemical Formula
Molecular Weight
Mechanism of Action
- Gramacidin - disrupts bacterial cell walls
- Neomycin - inhibits bacterial protein synthesis
- Polymyxin B - disrupts bacterial cell membranes
Indications
- Topical treatment of bacterial skin infections
- Prevention of infection in minor cuts, scrapes, and burns
Common Dosage Forms
- Ointment
- Cream
- Solution
Typical Dosage
- Apply a thin layer to affected area 1-3 times daily
Pediatric Dosage
- Consult healthcare provider for appropriate dosage
Geriatric Dosage
- Consult healthcare provider for appropriate dosage
Side Effects
- Skin irritation
- Allergic reactions (rare)
Contraindications
- Hypersensitivity to any component in the formulation
Pregnancy Category
- Category C - Animal reproduction studies have shown an adverse effect on the fetus, and there are no adequate and well-controlled studies in humans
Lactation Safety
- Use with caution, may pass into breast milk
Drug Interactions
- No significant drug interactions reported with topical use
Overdose Symptoms
Antidote for Overdose
Storage Conditions
- Store at room temperature (15-30°C)
- Protect from light and moisture
Pharmacokinetics
- Absorption: Minimal systemic absorption after topical application
- Distribution: Not well documented
- Metabolism: Not metabolized systemically
- Excretion: Not well documented
Precautions
- Avoid contact with eyes and mucous membranes
- Use with caution in patients with a history of allergies
Warnings
- For external use only
- Not for use on deep or puncture wounds