Triamcinolone + Neomycin + Nystatin + Gramicidin

Generic Name

Triamcinolone-Neomycin-Nystatin-Gramicidin

Other Names

• Trianestine
• Quadritop

Drug Class

• Topical corticosteroid with antibacterial and antifungal agents

Chemical Formula

Molecular Weight

Mechanism of Action

• Triamcinolone: anti-inflammatory
• Neomycin: inhibits bacterial protein synthesis
• Nystatin: interferes with fungal cell membrane permeability
• Gramicidin: disrupts bacterial cell membrane function

Indications

• Dermatitis
• Eczema
• Skin infections with bacteria or fungi

Common Dosage Forms

• Cream
• Ointment

Typical Dosage

• Apply a thin layer to affected area 2-4 times daily

Pediatric Dosage

• Use under pediatrician's guidance

Geriatric Dosage

• Use with caution due to potential skin thinning and increased absorption

Side Effects

• Skin irritation
• Burning sensation
• Itching
• Redness
• Dryness

Contraindications

• Hypersensitivity to any component
• Intranasal or ophthalmic use

Pregnancy Category

• C (triamcinolone)

Lactation Safety

• Caution advised

Drug Interactions

• None significant for topical use

Overdose Symptoms

• Potential for systemic corticosteroid effects if large quantities are absorbed

Antidote for Overdose

• Supportive care and monitoring

Storage Conditions

• Store at room temperature away from moisture and heat

Pharmacokinetics

• Absorption: Low systemic absorption with topical use
• Distribution: N/A
• Metabolism: N/A
• Excretion: N/A

Precautions

• Avoid prolonged use
• Avoid contact with eyes or mucous membranes

Warnings

• Do not cover treated area with airtight dressings unless directed by healthcare provider

Others

• For external use only