Aminocaproic acid
Generic Details
Generic Name
Aminocaproic Acid
Other Names
- Epsilon-Aminocaproic Acid
- EACA
Drug Class
- Antifibrinolytic
Chemical Formula
C6H13NO2
Molecular Weight
131.18 g/mol
Mechanism of Action
- Inhibits the activation of plasminogen to plasmin, thus preventing the breakdown of blood clots.
Indications
- Bleeding disorders associated with increased fibrinolytic activity such as after cardiac surgery, traumatic injury, or certain medical conditions like hemophilia or liver disease.
Common Dosage Forms
- Tablet
- Solution for injection
Typical Dosage
- Initial dose: 4 to 5 grams orally or intravenously, followed by a maintenance dose of 1 gram per hour.
Pediatric Dosage
- Dosage varies based on age and weight; consult with a pediatrician.
Geriatric Dosage
- Adjust dosage based on renal function and individual patient response.
Side Effects
- Nausea
- Vomiting
- Diarrhea
- Dizziness
- Hypotension
Contraindications
- Hypersensitivity to aminocaproic acid
- History of thrombosis
Pregnancy Category
- Category C - Risk cannot be ruled out, benefits should outweigh risks.
Lactation Safety
- Limited data available, consult healthcare provider before use.
Drug Interactions
- May interact with anticoagulants and thrombolytics, increasing the risk of thrombosis.
Overdose Symptoms
- Seizures
- Hypotension
- Bradycardia
Antidote for Overdose
- No specific antidote; manage symptoms and provide supportive care.
Storage Conditions
- Store at room temperature away from moisture and heat.
Pharmacokinetics
- Absorption: Rapidly absorbed after oral administration
- Distribution: Distributed widely in body tissues
- Metabolism: Undergoes minimal metabolism in the liver
- Excretion: Excreted unchanged in the urine
Precautions
- Use with caution in patients with a history of renal impairment or thromboembolic events.
Warnings
- Monitor for signs of thrombosis during therapy.
Others
- Aminocaproic Acid is also used off-label in the management of acute upper gastrointestinal bleeding.