Ramipril + Hydrochlorothiazide
Generic Details
Generic Name
Ramipril-Hydrochlorothiazide
Other Names
Drug Class
- Antihypertensive Combination
Chemical Formula
Molecular Weight
Mechanism of Action
- Ramipril: ACE inhibitor - inhibits angiotensin-converting enzyme
- Hydrochlorothiazide: Thiazide diuretic - increases excretion of sodium and water by inhibiting sodium reabsorption in the distal convoluted tubule
Indications
- Hypertension (high blood pressure)
Common Dosage Forms
- Tablet
Typical Dosage
- One tablet of ramipril-hydrochlorothiazide once daily
Pediatric Dosage
Geriatric Dosage
Side Effects
- Cough
- Dizziness
- Hyperkalemia
- Hypotension
- Renal impairment
- Electrolyte abnormalities
Contraindications
- History of angioedema related to previous ACE inhibitor therapy
- Renal artery stenosis
- Anuria
- Hypersensitivity to sulfa drugs
Pregnancy Category
- D (1st trimester) - Unsafe
Lactation Safety
- Limited data - Caution advised
Drug Interactions
- NSAIDs may reduce antihypertensive effects
- Potassium-sparing diuretics may increase potassium levels
- Alcohol may enhance hypotensive effects
Overdose Symptoms
- Hypotension
- Electrolyte abnormalities
- Renal failure
Antidote for Overdose
- Symptomatic and supportive treatment
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed
- Distribution: Protein binding: Ramipril - 73%, Hydrochlorothiazide - 40-68%
- Metabolism: Ramipril - hepatic to ramiprilat, Hydrochlorothiazide - minimal metabolism
- Excretion: Primarily renal
Precautions
- Hypovolemia
- Hyperkalemia
- Renal impairment
Warnings
- Fetal toxicity
- Hypotension
- Impaired renal function
Others
- Close monitoring of electrolytes and renal function recommended