Telmisartan + Hydrochlorothiazide

Generic Details

Generic Name

Telmisartan-Hydrochlorothiazide

Other Names

  • Micardis HCT
  • Telsar-H

Drug Class

  • Angiotensin II Receptor Blocker (ARB) and Thiazide Diuretic Combination

Chemical Formula

C33H30N4O2S2.C7H8ClN3O4S2

Molecular Weight

≈ 900.05 g/mol

Mechanism of Action

  • Telmisartan blocks the action of angiotensin II, leading to vasodilation and decreased secretion of aldosterone
  • Hydrochlorothiazide works by increasing the excretion of sodium and water by inhibiting reabsorption in the kidneys.

Indications

  • Hypertension (high blood pressure)

Common Dosage Forms

  • Tablet

Typical Dosage

  • Telmisartan 40mg-Hydrochlorothiazide 12.5mg or Telmisartan 80mg-Hydrochlorothiazide 12.5mg once daily

Pediatric Dosage

    Geriatric Dosage

      Side Effects

      • Dizziness
      • Hypotension
      • Hyperkalemia
      • Renal dysfunction
      • Electrolyte abnormalities

      Contraindications

      • History of angioedema related to previous treatment with ACE inhibitors
      • Anuria
      • Severe renal impairment (CrCl < 30mL/min)
      • Hypersensitivity to sulfonamide-derived drugs

      Pregnancy Category

      • Category D - Telmisartan may cause fetal harm when administered to pregnant women

      Lactation Safety

      • Excretion in breast milk is unknown; Telmisartan is not recommended while breastfeeding.

      Drug Interactions

      • Lithium
      • Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
      • Potassium-sparing diuretics
      • Digoxin

      Overdose Symptoms

      • Hypotension
      • Dehydration
      • Electrolyte abnormalities

      Antidote for Overdose

      • Supportive measures and symptomatic treatment

      Storage Conditions

      • Store at room temperature between 20-25°C (68-77°F)

      Pharmacokinetics

      • Absorption: Telmisartan: Rapidly absorbed with peak plasma concentrations reached in 0.5-1 hour; Bioavailability approximately 42%
      • Distribution: Telmisartan: Highly bound to plasma proteins (>99.5%); Hydrochlorothiazide: Widely distributed
      • Metabolism: Telmisartan: Minimal hepatic metabolism via conjugation to inactive metabolites
      • Excretion: Telmisartan: Eliminated primarily via feces (97%) and urine (1%); Hydrochlorothiazide: Eliminated mainly through urine

      Precautions

      • Renal impairment
      • Hepatic impairment
      • Electrolyte imbalances
      • Diabetes mellitus

      Warnings

      • Hypotension
      • Hyperkalemia
      • Acute angle-closure glaucoma
      • Renal impairment
      • Hepatic impairment

      Others