Hydrochlorothiazide + Triamterene

Generic Details

Generic Name

Hydrochlorothiazide-Triamterene

Other Names

  • Dyazide
  • Maxzide

Drug Class

  • Diuretic combination

Chemical Formula

C7H8ClN3O4S2 - Hydrochlorothiazide, C12H11N7 - Triamterene

Molecular Weight

297.73 g/mol - Hydrochlorothiazide, 253.27 g/mol - Triamterene

Mechanism of Action

  • Hydrochlorothiazide - inhibits sodium and chloride reabsorption in the distal renal tubules
  • Triamterene - inhibits sodium reabsorption in exchange for potassium ions in the distal tubule

Indications

  • Hypertension
  • Edema associated with congestive heart failure
  • Nephrotic syndrome

Common Dosage Forms

  • Tablet

Typical Dosage

  • Hydrochlorothiazide: 25-50 mg once daily
  • Triamterene: 50 mg once daily

Pediatric Dosage

  • Dosage based on body weight and condition, under the guidance of a healthcare provider.

Geriatric Dosage

  • Dosage adjustment may be necessary due to age-related changes in renal function.

Side Effects

  • Hypotension
  • Hyperkalemia
  • Hypokalemia
  • Dehydration
  • Photosensitivity
  • Renal impairment
  • Electrolyte disturbances

Contraindications

  • Anuria
  • Severe renal impairment
  • Hypersensitivity to sulfonamides or triamterene

Pregnancy Category

  • Category C - Hydrochlorothiazide
  • Category C - Triamterene

Lactation Safety

  • Use with caution, benefits should outweigh risks

Drug Interactions

  • NSAIDs may reduce the diuretic, natriuretic, and antihypertensive effects
  • Lithium toxicity risk may increase

Overdose Symptoms

  • Electrolyte disturbances
  • Dehydration
  • Hypotension
  • Renal failure

Antidote for Overdose

  • Supportive care and correction of electrolyte imbalances

Storage Conditions

  • Store at room temperature away from moisture and heat

Pharmacokinetics

  • Absorption: Well absorbed from the gastrointestinal tract
  • Distribution: Hydrochlorothiazide - Crosses the placenta, Triamterene - Unknown
  • Metabolism: Triamterene undergoes hepatic metabolism
  • Excretion: Hydrochlorothiazide - Renal excretion, Triamterene - Renal excretion

Precautions

  • Monitor serum potassium, sodium levels and renal function regularly

Warnings

  • Hyperkalemia risk in renal impairment
  • Photosensitivity precautions
  • Monitor for signs of dehydration

Others

  • It is important to follow a potassium-rich diet while taking this medication.