Hydrocortisone + Neomycin Sulphate + Polymixin B

Generic Name

Hydrocortisone-Neomycin Sulphate-Polymyxin B

Other Names

• Hydrocortisone-Neomycin-Polymyxin B Ophthalmic

Drug Class

• Topical Corticosteroid with Antibiotics

Chemical Formula

Molecular Weight

Mechanism of Action

• Hydrocortisone: anti-inflammatory, Neomycin: protein synthesis inhibitor, Polymyxin B: disrupts bacterial cell membrane

Indications

• Eye infections, inflammation, and associated discomfort

Common Dosage Forms

• Ophthalmic ointment
• Eye drops

Typical Dosage

• Apply a small amount to the affected eye(s) 2-4 times daily

Pediatric Dosage

• Consult pediatrician for appropriate dosage

Geriatric Dosage

• May require dosage adjustments; consult healthcare provider

Side Effects

• Temporary burning or stinging sensation, blurred vision, allergic reactions

Contraindications

• Hypersensitivity to components, viral eye infections, fungal eye infections

Pregnancy Category

• Category C - Safety not established, use only if benefits outweigh risks

Lactation Safety

• Use with caution, consult healthcare provider

Drug Interactions

• No significant drug interactions reported

Overdose Symptoms

• Unlikely with topical use, may cause increased side effects if ingested

Antidote for Overdose

• Not applicable due to topical administration

Storage Conditions

• Store at room temperature away from moisture and heat

Pharmacokinetics

• Absorption: Limited systemic absorption through the eye
• Distribution: Limited distribution in the body
• Metabolism: Metabolized locally in the eye
• Excretion: Mainly eliminated through tears

Precautions

• Do not wear contact lenses during treatment
• Avoid touching the tip of the medication container to prevent contamination

Warnings

• Discontinue use if irritation or allergic reactions occur
• Prolonged use may lead to fungal overgrowth

Others

• Follow the exact dosage and duration prescribed by the healthcare provider