Miconazole Nitrate + Hydrocortisone

Generic Name

Miconazole Nitrate Hydrocortisone

Other Names

• Miconazole-Hydrocortisone Cream
• Cortifoam-M

Drug Class

• Antifungal
• Topical Steroid

Chemical Formula

Molecular Weight

Mechanism of Action

• Miconazole: Antifungal action by inhibiting ergosterol synthesis
• Hydrocortisone: Anti-inflammatory by suppressing the immune response

Indications

• Treatment of fungal skin infections complicated by inflammation and itching

Common Dosage Forms

• Cream
• Ointment

Typical Dosage

• Apply a thin layer to affected area 2-3 times daily

Pediatric Dosage

• Consult healthcare provider for appropriate dosing in children

Geriatric Dosage

• May require adjustment based on individual health status

Side Effects

• Burning sensation
• Itching
• Irritation at application site

Contraindications

• Hypersensitivity to miconazole or hydrocortisone components
• Certain skin conditions like acne or rosacea

Pregnancy Category

• Category C - Risk cannot be ruled out

Lactation Safety

• Use with caution, consult healthcare provider

Drug Interactions

• May interact with certain corticosteroids or antifungal medications

Overdose Symptoms

• Excessive skin irritation
• Prolonged use may lead to systemic effects of corticosteroids

Antidote for Overdose

• Discontinue use and seek medical attention

Storage Conditions

• Store at room temperature away from moisture and heat

Pharmacokinetics

• Absorption: Topical application, minimal systemic absorption
• Distribution: Limited distribution in the body
• Metabolism: Metabolized in the skin
• Excretion: Primarily excreted via urine

Precautions

• Avoid contact with eyes and mucous membranes
• Not for use on broken or infected skin

Warnings

• Prolonged use may lead to skin thinning or other corticosteroid-related effects

Others

• Always follow the prescribed regimen and duration of use.