Hyoscine Butylbromide
Generic Details
Generic Name
Hyoscine-Butylbromide
Other Names
- Butylscopolamine
- Scopolamine Butylbromide
- Buscopan
Drug Class
- Antimuscarinic
- Anticholinergic
Chemical Formula
C21H30BrNO4
Molecular Weight
440.38 g/mol
Mechanism of Action
- Blocks muscarinic receptors in the smooth muscle, causing relaxation
Indications
- Relief of abdominal pain and cramps associated with gastrointestinal disorders
- Gallbladder and urinary disorders
- Irritable bowel syndrome (IBS)
Common Dosage Forms
- Tablet
- Injection
- Suppository
Typical Dosage
- 10-20 mg 3-5 times a day
Pediatric Dosage
- Not recommended for children under 6 years
Geriatric Dosage
- Lower initial doses may be required due to decreased metabolism and excretion
Side Effects
- Dry mouth
- Blurred vision
- Constipation
- Urinary retention
- Dizziness
Contraindications
- Glaucoma
- Myasthenia gravis
- Megacolon
- Hypersensitivity to hyoscine derivatives
Pregnancy Category
- Not recommended during pregnancy unless the benefits outweigh the risks
Lactation Safety
- Limited data available, use with caution
Drug Interactions
- Enhanced anticholinergic effects with other antimuscarinic drugs
- May enhance the sedative effects of CNS depressants
Overdose Symptoms
- Severe anticholinergic effects such as hallucinations, delirium, seizures
Antidote for Overdose
- Physostigmine
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed orally
- Distribution: Crosses the blood-brain barrier poorly
- Metabolism: Partially metabolized in the liver
- Excretion: Mainly excreted in the urine
Precautions
- Use with caution in patients with a history of glaucoma or urinary retention
Warnings
- May cause drowsiness, avoid driving or operating machinery until effects are known
Others
- Use with caution in the elderly due to increased susceptibility to anticholinergic side effects