Amiodarone Hydrochloride
Generic Details
Generic Name
Amiodarone Hydrochloride
Other Names
- Cordarone
- Pacerone
Drug Class
- Antiarrhythmic
Chemical Formula
C25H29I2NO3.HCl
Molecular Weight
681.77 g/mol
Mechanism of Action
- Blocks potassium, sodium, and calcium channels, prolonging action potential duration
Indications
- Treatment of ventricular and supraventricular arrhythmias
Common Dosage Forms
- Oral tablets
- Intravenous solution
Typical Dosage
- 200-400 mg orally once or twice daily
Pediatric Dosage
- Not established
Geriatric Dosage
- Lower initial doses
Side Effects
- Bradycardia
- Corneal microdeposits
- Hypothyroidism
- Photosensitivity
Contraindications
- Sinus node dysfunction
- Bradycardia
- Heart block
Pregnancy Category
- D
Lactation Safety
- L3 - Moderately safe
Drug Interactions
- Warfarin
- Digoxin
- Phenytoin
Overdose Symptoms
- Hypotension
- Bradycardia
- Cardiac arrest
Antidote for Overdose
- No specific antidote, supportive care
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Variable oral bioavailability
- Distribution: Extensive distribution in adipose tissue and highly perfused organs
- Metabolism: Hepatic metabolism via CYP3A4
- Excretion: Primarily in feces
Precautions
- Monitor thyroid function regularly
- Regular eye exams for vision changes
Warnings
- Potential for proarrhythmic effects
- Pulmonary toxicity risk