Ibandronic Acid
Generic Details
Generic Name
Ibandronic Acid
Other Names
- Boniva
Drug Class
- Bisphosphonate
Chemical Formula
C9H23NO8P2
Molecular Weight
357.146 g/mol
Mechanism of Action
- Inhibits bone resorption by osteoclasts
Indications
- Treatment and prevention of osteoporosis in postmenopausal women
- Treatment of bone metastases from various cancers
Common Dosage Forms
- Tablets
- Injection
Typical Dosage
- 2.5 mg oral tablet once daily
- 3 mg intravenous injection every 3 months
Pediatric Dosage
- Not recommended for use in children
Geriatric Dosage
- No dosage adjustment needed
Side Effects
- Gastrointestinal disturbances (nausea, diarrhea)
- Bone pain
- Muscle pain
- Headache
- Flu-like symptoms
Contraindications
- Hypersensitivity to bisphosphonates
- Hypocalcemia
Pregnancy Category
- Not recommended for use during pregnancy
Lactation Safety
- Not recommended during breastfeeding
Drug Interactions
- Avoid concurrent use with calcium supplements, antacids, and certain other medications
Overdose Symptoms
- Hypocalcemia
- Hypophosphatemia
- Hypomagnesemia
Antidote for Overdose
- No specific antidote, manage symptoms supportively
Storage Conditions
- Store at room temperature away from light and moisture
Pharmacokinetics
- Absorption: Poor oral bioavailability
- Distribution: Binds to bone tissues
- Metabolism: Minimal hepatic metabolism
- Excretion: Excreted unchanged in urine
Precautions
- Patients should remain upright for at least 60 minutes after oral dosing to reduce the risk of esophageal irritation
Warnings
- Risk of severe bone, joint, or muscle pain
- Osteonecrosis of the jaw