Indapamide
Generic Details
Generic Name
Indapamide
Other Names
- Lozol
- Natrilix
Drug Class
- Diuretic
- Thiazide-like diuretic
Chemical Formula
C16H16ClN3O3S
Molecular Weight
365.83 g/mol
Mechanism of Action
- Indapamide inhibits the reabsorption of sodium and chloride in the distal convoluted tubule of the kidneys, leading to increased excretion of water and electrolytes.
Indications
- Hypertension
- Edema associated with congestive heart failure
- Edema associated with renal dysfunction
Common Dosage Forms
- Tablet
- Extended-release tablet
Typical Dosage
- 1.25-5 mg once daily
Pediatric Dosage
- Not established
Geriatric Dosage
- Dosage adjustment may be needed based on renal function
Side Effects
- Hypokalemia
- Hyponatremia
- Hypomagnesemia
- Hypotension
- Dizziness
- Headache
Contraindications
- Anuria
- Severe renal impairment
- Hypersensitivity to sulfonamides
Pregnancy Category
- C - Use with caution
Lactation Safety
- Compatible with breastfeeding
Drug Interactions
- Lithium - may increase lithium levels
- Digoxin - may increase digoxin levels
Overdose Symptoms
- Hypokalemia
- Hyponatremia
- Dehydration
Antidote for Overdose
- Treatment is supportive and symptomatic
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Rapidly and well absorbed from the gastrointestinal tract
- Distribution: Mainly bound to plasma proteins
- Metabolism: Metabolized in the liver
- Excretion: Primarily excreted unchanged in the urine
Precautions
- Monitor electrolyte levels regularly
- Avoid abrupt discontinuation
Warnings
- May cause hypokalemia and other electrolyte imbalances
Others
- Indapamide is often used in combination with other antihypertensive agents for better blood pressure control.