Amlexanox

Generic Details

Generic Name

Amlexanox

Other Names

  • Aphthasol
  • Aphtasolon

Drug Class

  • Anti-inflammatory
  • Anti-allergic

Chemical Formula

C16H14N2O4

Molecular Weight

298.29 g/mol

Mechanism of Action

  • Inhibits the release of inflammatory mediators such as leukotrienes and histamine

Indications

  • Treatment of aphthous ulcers (canker sores)

Common Dosage Forms

  • Oral paste

Typical Dosage

  • Apply a small amount of paste to the affected area 4 times daily

Pediatric Dosage

  • Safety and efficacy not established in children under 12 years

Geriatric Dosage

  • No specific dosage adjustments recommended for the elderly

Side Effects

  • Stinging or burning sensation at application site
  • Increased sensitivity to sunlight

Contraindications

  • Hypersensitivity to amlexanox or any component of the formulation

Pregnancy Category

  • Category C - Safety in pregnancy has not been established

Lactation Safety

  • Unknown if excreted in breast milk, use caution

Drug Interactions

  • No significant drug interactions reported

Overdose Symptoms

  • Limited information available

Antidote for Overdose

  • No specific antidote, symptomatic treatment recommended

Storage Conditions

  • Store at room temperature (20-25°C)

Pharmacokinetics

  • Absorption: Well absorbed after oral administration
  • Distribution: Protein binding is moderate
  • Metabolism: Metabolized in the liver
  • Excretion: Excreted in urine and feces

Precautions

  • Avoid contact with eyes and mucous membranes

Warnings

  • Discontinue use if skin rash or irritation develops
  • Not for the treatment of viral infections such as cold sores or fever blisters

Others

  • Available only by prescription