Amlodipine Besilate

Generic Details

Generic Name

Amlodipine Besilate

Other Names

  • Norvasc

Drug Class

  • Calcium Channel Blocker

Chemical Formula

C20H25ClN2O5

Molecular Weight

408.88 g/mol

Mechanism of Action

  • Blocks calcium influx into vascular smooth muscle and cardiac muscle cells, resulting in vasodilation and decreased myocardial contractility

Indications

  • Hypertension
  • Angina

Common Dosage Forms

  • Tablet

Typical Dosage

  • 5-10 mg once daily

Pediatric Dosage

  • Not established

Geriatric Dosage

  • Start at the lower end of the dosing range

Side Effects

  • Peripheral edema
  • Headache
  • Flushing
  • Dizziness
  • Fatigue

Contraindications

  • Hypersensitivity to amlodipine
  • Severe hypotension

Pregnancy Category

  • Category C

Lactation Safety

  • Use with caution

Drug Interactions

  • CYP3A4 inhibitors (e.g., macrolide antibiotics) may increase amlodipine levels

Overdose Symptoms

  • Hypotension
  • Bradycardia

Antidote for Overdose

  • Intravenous calcium infusion

Storage Conditions

  • Store at room temperature away from light and moisture

Pharmacokinetics

  • Absorption: Well-absorbed orally
  • Distribution: Extensively distributed in the body
  • Metabolism: Metabolized in the liver to inactive metabolites
  • Excretion: Eliminated mainly via urine

Precautions

  • Monitor for signs of peripheral edema
  • Caution in patients with severe hepatic impairment

Warnings

  • Risk of hypotension
  • Avoid sudden withdrawal

Others

  • Amlodipine besilate is a commonly prescribed medication for hypertension and angina. It is well-tolerated in most patients but may cause peripheral edema as a common side effect.