Irbesartan
Generic Details
Generic Name
Irbesartan
Other Names
- Avapro
Drug Class
- Angiotensin II Receptor Blocker
Chemical Formula
C25H28N6O
Molecular Weight
428.53 g/mol
Mechanism of Action
- Blocks the binding of angiotensin II to AT1 receptors, leading to vasodilation and reduced secretion of aldosterone
Indications
- Hypertension
- Diabetic Nephropathy
- Heart Failure (off-label)
Common Dosage Forms
- Tablet
Typical Dosage
- 150-300 mg once daily
Pediatric Dosage
- Not established
Geriatric Dosage
- Dosage adjustments may be needed based on renal function
Side Effects
- Dizziness
- Hypotension
- Hyperkalemia
- Headache
- Fatigue
Contraindications
- Hypersensitivity to irbesartan or any component of the formulation
- Pregnancy
Pregnancy Category
- D
Lactation Safety
- Use with caution; consider alternatives
Drug Interactions
- Potassium-sparing diuretics
- NSAIDs
- Lithium
Overdose Symptoms
- Hypotension
- Bradycardia
Antidote for Overdose
- Intravenous fluids
- Vasopressors if necessary
Storage Conditions
- Store at room temperature away from light and moisture
Pharmacokinetics
- Absorption: Rapidly absorbed after oral administration
- Distribution: Irbesartan is highly bound to plasma proteins
- Metabolism: Primarily metabolized by CYP2C9 and CYP3A4 enzymes
- Excretion: Excreted predominantly in feces and urine
Precautions
- Renal Impairment
- Hepatic Impairment
- Hyperkalemia
Warnings
- Risk of fetal injury in pregnancy
Others
- It may take up to 4-6 weeks for maximum blood pressure reduction