Amlodipine Besilate + Atenolol

Generic Details

Generic Name

Amlodipine Besilate Atenolol

Other Names

  • Amlodipine-Atenolol Combination

Drug Class

  • Calcium Channel Blocker
  • Beta Blocker

Chemical Formula

C33H42N2O9

Molecular Weight

610.7 g/mol

Mechanism of Action

  • Amlodipine: Calcium channel blockade leading to vasodilation
  • Atenolol: Beta-adrenergic receptor blockade leading to decreased heart rate and blood pressure

Indications

  • Hypertension
  • Angina

Common Dosage Forms

  • Tablet

Typical Dosage

  • 5 mg amlodipine/50 mg atenolol once daily, can be titrated based on individual response

Pediatric Dosage

  • Safety and efficacy not established in children

Geriatric Dosage

  • Dose adjustment may be required based on renal function

Side Effects

  • Dizziness
  • Fatigue
  • Peripheral edema
  • Bradycardia
  • Hypotension

Contraindications

  • Cardiogenic shock
  • Heart block greater than first degree
  • Untreated pheochromocytoma

Pregnancy Category

  • C (amlodipine)
  • D (atenolol)

Lactation Safety

  • L3 (Moderate Risk)

Drug Interactions

  • Potassium-sparing diuretics may increase potassium levels when used with amlodipine

Overdose Symptoms

  • Hypotension
  • Bradycardia
  • Cardiac failure

Antidote for Overdose

  • Atropine for bradycardia; glucagon for hypotension

Storage Conditions

  • Store at room temperature away from moisture and heat

Pharmacokinetics

  • Absorption: Well-absorbed orally
  • Distribution: Amlodipine: Extensively bound to plasma proteins; Atenolol: Penetrates the blood-brain barrier poorly
  • Metabolism: Amlodipine: Hepatic metabolism; Atenolol: Minimal hepatic metabolism
  • Excretion: Amlodipine: Urine (60-90% unchanged); Atenolol: Urine (unchanged)

Precautions

  • Renal impairment
  • Hepatic impairment
  • Diabetes

Warnings

  • Abrupt discontinuation may lead to rebound hypertension or angina

Others

  • This combination medication is used when monotherapy is not sufficient to control blood pressure.