Amlodipine Besilate + Benazepril Hydrochloride
Generic Details
Generic Name
Amlodipine Besilate Benazepril Hydrochloride
Other Names
- Amlodipine-Besylate Benazepril HCl
Drug Class
- Antihypertensive Combination
Chemical Formula
C27H29Cl2N5O6
Molecular Weight
596.45 g/mol
Mechanism of Action
- Amlodipine: Calcium Channel Blocker
- Benazepril: ACE Inhibitor
Indications
- Hypertension
- Chronic stable angina
Common Dosage Forms
- Tablet
Typical Dosage
- One tablet orally once a day
Pediatric Dosage
- Safety and efficacy not established in children
Geriatric Dosage
- Dose adjustment may be necessary in the elderly
Side Effects
- Hypotension
- Cough
- Edema
- Dizziness
- Headache
Contraindications
- History of angioedema with ACE inhibitors
- Severe aortic stenosis
Pregnancy Category
- Category D
Lactation Safety
- Lactation is not recommended
Drug Interactions
- Potassium-sparing diuretics
- NSAIDs
- ACE Inhibitors
Overdose Symptoms
- Hypotension
- Tachycardia
- Bradycardia
Antidote for Overdose
- Supportive measures
Storage Conditions
- Store at room temperature away from light and moisture
Pharmacokinetics
- Absorption: Well absorbed
- Distribution: Protein binding: Amlodipine 97%, Benazepril 93%
- Metabolism: Benazepril - Hepatic; Amlodipine - slight hepatic metabolism
- Excretion: Mainly renal
Precautions
- Renal impairment
- Hepatic impairment
- Hypotension
Warnings
- Angioedema
- Hypotension
- Renal Impairment