Ivermectin (Tablet)

Generic Details

Generic Name

Ivermectin Tablet

Other Names

  • Ivermectin Tablet

Drug Class

  • Anthelmintic

Chemical Formula

C48H74O14

Molecular Weight

875.10 g/mol

Mechanism of Action

  • Binds selectively and with high affinity to glutamate-gated chloride ion channels in invertebrate muscle and nerve cells of helminths, causing an increase in the permeability of the cell membrane.

Indications

  • Treatment of parasitic infections such as strongyloidiasis, onchocerciasis, and scabies.

Common Dosage Forms

  • Tablet

Typical Dosage

  • 150 to 200 mcg/kg as a single dose

Pediatric Dosage

  • Dosing based on weight, consult a pediatrician

Geriatric Dosage

  • Dosage adjustment may be needed, consult a healthcare provider

Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Dizziness
  • Fatigue

Contraindications

  • Hypersensitivity to ivermectin

Pregnancy Category

  • C - Use with caution

Lactation Safety

  • Limited data available, consult a healthcare provider

Drug Interactions

  • Caution with drugs that inhibit P-glycoprotein

Overdose Symptoms

  • Drowsiness
  • Dizziness
  • Tremor
  • Blurred Vision

Antidote for Overdose

  • There is no specific antidote; treatment is supportive

Storage Conditions

  • Store at room temperature (20-25°C)

Pharmacokinetics

  • Absorption: Well absorbed after oral administration
  • Distribution: Concentrates in the liver and adipose tissue
  • Metabolism: Metabolized in the liver
  • Excretion: Excreted mainly in feces

Precautions

  • Caution in patients with liver disease

Warnings

  • Not for use in children weighing <15 kg

Others

  • Avoid alcohol consumption while taking ivermectin.