Ketoprofen (oral & injection)
Generic Details
Generic Name
Ketoprofen Oral Injection
Other Names
- Orudis
- Oruvail
Drug Class
- Nonsteroidal Anti-Inflammatory Drug (NSAID)
Chemical Formula
C16H14O3
Molecular Weight
254.28 g/mol
Mechanism of Action
- Inhibits the enzyme cyclooxygenase, reducing prostaglandin synthesis
Indications
- Pain relief associated with osteoarthritis
- Rheumatoid arthritis
- Dysmenorrhea
- Acute gout
- Postoperative pain
Common Dosage Forms
- Oral capsules
- Oral solutions
- Intravenous injections
Typical Dosage
- 75-300 mg per day divided into 2-4 doses
Pediatric Dosage
- Limited safety data available, consult pediatrician
Geriatric Dosage
- Lower initial doses and monitoring for adverse effects recommended
Side Effects
- Gastrointestinal disturbances
- Renal impairment
- Hypersensitivity reactions
- Elevated liver enzymes
Contraindications
- History of NSAID-induced asthma
- Active peptic ulcer disease
- Severe heart failure
Pregnancy Category
- Category C - Avoid use in the third trimester
Lactation Safety
- Limited data available, use caution
Drug Interactions
- Avoid concurrent use with other NSAIDs or anticoagulants
Overdose Symptoms
- Severe headache
- Nausea
- Vomiting
- GI bleeding
Antidote for Overdose
- No specific antidote, manage symptoms and provide supportive care
Storage Conditions
- Store at controlled room temperature between 20-25°C (68-77°F)
Pharmacokinetics
- Absorption: Rapidly and completely absorbed after oral administration
- Distribution: Widely distributed in body tissues
- Metabolism: Undergoes hepatic metabolism
- Excretion: Primarily excreted in the urine
Precautions
- Monitor renal function periodically
- Avoid in patients with heart failure or hypertension
Warnings
- Increased risk of cardiovascular events and gastrointestinal bleeding
Others
- Caution in patients with a history of peptic ulcer disease or GI bleeding