Ketotifen Fumarate (Oral)
Generic Details
Generic Name
Ketotifen Fumarate Oral
Other Names
- Ketotifen
- Zaditor
- Alaway
Drug Class
- Antihistamine
- Mast cell stabilizer
Chemical Formula
C19H19NOS.C4H4O4
Molecular Weight
425.5 g/mol
Mechanism of Action
- Blocks histamine receptors
- Stabilizes mast cells
Indications
- Allergic conjunctivitis
- Allergic rhinitis
- Asthma
Common Dosage Forms
- Tablet
- Syrup
Typical Dosage
- 1 mg twice daily
Pediatric Dosage
- Consult healthcare provider for appropriate dosage
Geriatric Dosage
- Lower initial doses may be necessary in elderly patients
Side Effects
- Drowsiness
- Dry mouth
- Headache
- Weight gain
Contraindications
- Hypersensitivity to ketotifen
- Pregnancy
Pregnancy Category
- Category C - Safety not established
Lactation Safety
- Limited data available, consult healthcare provider
Drug Interactions
- Avoid concomitant use with CNS depressants
Overdose Symptoms
- Confusion
- Hallucinations
- Seizures
Antidote for Overdose
- Supportive care and symptomatic treatment
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed from the gastrointestinal tract
- Distribution: Crosses the blood-brain barrier and placenta; enters breast milk
- Metabolism: Hepatic
- Excretion: Primarily in urine
Precautions
- Use with caution in patients with renal impairment
- Monitor for drowsiness
Warnings
- May cause drowsiness, avoid driving or operating machinery until effects are known
Others
- Do not exceed recommended dosage