Amlodipine Besilate + Olmesartan Medoxomil
Generic Details
Generic Name
Amlodipine Besilate Olmesartan Medoxomil
Other Names
- Amlodipine-Olmesartan
Drug Class
- Calcium Channel Blocker
- Angiotensin II Receptor Antagonist
Chemical Formula
C33H36N6O6.C30H26ClN3O9S
Molecular Weight
1113.27 g/mol
Mechanism of Action
- Amlodipine: Blocks calcium channels
- Olmesartan: Blocks angiotensin II receptor
Indications
- Hypertension
- Reducing the risk of strokes
- Treatment of coronary artery disease
Common Dosage Forms
- Tablets
Typical Dosage
- Amlodipine 5-10 mg / Olmesartan 20-40 mg once daily
Pediatric Dosage
- Safety and efficacy not established in pediatric patients
Geriatric Dosage
- Dosage adjustment may be needed in elderly patients
Side Effects
- Dizziness
- Fatigue
- Swelling in ankles or feet
- Hypotension
Contraindications
- Known hypersensitivity to any component
- Pregnancy
- Severe renal impairment
Pregnancy Category
- D
Lactation Safety
- Should not be used during lactation
Drug Interactions
- Potassium-sparing diuretics
- NSAIDs
- Lithium
Overdose Symptoms
- Severe hypotension
- Bradycardia
Antidote for Overdose
- Supportive measures and activated charcoal
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed orally
- Distribution: Protein binding percentage: Amlodipine 97%, Olmesartan 99%
- Metabolism: Metabolized in the liver
- Excretion: Primarily renal
Precautions
- Monitor blood pressure regularly
- Caution in hepatic impairment
Warnings
- Hypotension risk
- Fetal toxicity risk