Lacidipine
Generic Details
Generic Name
Lacidipine
Other Names
- Lacipil
Drug Class
- Calcium channel blocker
Chemical Formula
C29H33NO6
Molecular Weight
491.6 g/mol
Mechanism of Action
- Inhibits the influx of calcium ions into smooth muscle cells, leading to vasodilation
Indications
- Hypertension
Common Dosage Forms
- Tablet
Typical Dosage
- 2-4 mg once daily
Pediatric Dosage
- Not established
Geriatric Dosage
- Lower initial doses may be necessary due to decreased clearance
Side Effects
- Headache
- Edema
- Dizziness
- Flushes
- Palpitations
Contraindications
- Hypersensitivity to lacidipine
- Pregnancy
- Severe hepatic impairment
Pregnancy Category
- Not recommended
Lactation Safety
- Not recommended
Drug Interactions
- CYP3A4 inhibitors such as ketoconazole may increase lacidipine levels
Overdose Symptoms
- Hypotension
- Tachycardia
Antidote for Overdose
- Intravenous calcium gluconate
Storage Conditions
- Store at room temperature away from light and moisture
Pharmacokinetics
- Absorption: Rapidly absorbed from the gastrointestinal tract
- Distribution: Highly protein bound
- Metabolism: Metabolized in the liver
- Excretion: Excreted in the urine and feces
Precautions
- Use with caution in patients with hepatic impairment
- Monitor blood pressure closely
Warnings
- Avoid abrupt withdrawal of lacidipine