Amlodipine Besilate + Telmisartan
Generic Details
Generic Name
Amlodipine Besilate Telmisartan
Other Names
- Amlodipine/Telmisartan
Drug Class
- Calcium Channel Blocker/Angiotensin II Receptor Blocker (ARB) Combination
Chemical Formula
C33H48N6O8S2
Molecular Weight
753.94 g/mol
Mechanism of Action
- Amlodipine: Calcium channel blocker
- Telmisartan: Angiotensin II receptor blocker
Indications
- Hypertension
- Coronary Artery Disease
- Prevention of Cardiovascular Events
Common Dosage Forms
- Tablet
Typical Dosage
- One tablet orally once a day
Pediatric Dosage
- Not established
Geriatric Dosage
- Dosage adjustment may be needed based on renal function
Side Effects
- Dizziness
- Edema
- Headache
- Hypotension
Contraindications
- History of angioedema with ACE inhibitors or ARBs
- Severe hepatic impairment
- Pregnancy
Pregnancy Category
- Category D - Avoid use in pregnancy
Lactation Safety
- Limited data available, use with caution
Drug Interactions
- Potassium-sparing diuretics
- ACE inhibitors
- NSAIDs
Overdose Symptoms
- Hypotension
- Bradycardia
Antidote for Overdose
- Intravenous fluids
- Vasopressors if needed
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Amlodipine: Well-absorbed; Telmisartan: Absolute bioavailability of about 42%
- Distribution: Both drugs extensively distributed in the body
- Metabolism: Amlodipine: Hepatic; Telmisartan: Hepatic
- Excretion: Primarily renal for both drugs
Precautions
- Renal impairment
- Hepatic impairment
- Heart Failure
Warnings
- Hypotension
- Hyperkalemia
- Renal Impairment
Others
- May increase the risk of hypotension if combined with alcohol or other antihypertensive medications