Lansoprazole
Generic Details
Generic Name
Lansoprazole
Other Names
- Prevacid
Drug Class
- Proton Pump Inhibitor
Chemical Formula
C16H14F3N3O2S
Molecular Weight
369.36 g/mol
Mechanism of Action
- Inhibits the proton pump in the gastric parietal cell, suppressing the secretion of gastric acid.
Indications
- Gastroesophageal Reflux Disease (GERD)
- Peptic Ulcer Disease
- Erosive Esophagitis
- Zollinger-Ellison Syndrome
Common Dosage Forms
- Capsules
- Oral Suspension
Typical Dosage
- 30 mg once daily for 4-8 weeks for most indications
Pediatric Dosage
- Dosage based on weight and severity of condition - consult a pediatrician
Geriatric Dosage
- Dosage adjustment may be needed based on renal function
Side Effects
- Headache
- Nausea
- Diarrhea
- Abdominal pain
- Flatulence
- Constipation
Contraindications
- Hypersensitivity to lansoprazole
- Severe liver disease
Pregnancy Category
- Category B - no evidence of risk in humans
Lactation Safety
- Safe to use while breastfeeding
Drug Interactions
- Warfarin
- Digoxin
- Theophylline
Overdose Symptoms
- Confusion
- Blurred vision
- Sweating
- Increased heart rate
Antidote for Overdose
- Symptomatic treatment and supportive measures
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Rapidly and completely absorbed after oral administration
- Distribution: Widely distributed in the body
- Metabolism: Primarily hepatic via CYP3A4
- Excretion: Mainly via urine
Precautions
- Monitor renal function in patients with impaired renal function
Warnings
- May increase the risk of Clostridium difficile-associated diarrhea