Amlodipine Besilate + Valsartan
Generic Details
Generic Name
Amlodipine Besilate Valsartan
Other Names
- Amlodipine Valsartan Combination
Drug Class
- Antihypertensive
Chemical Formula
C33H34N6O6S2
Molecular Weight
690.8 g/mol
Mechanism of Action
- Amlodipine: Calcium Channel Blocker
- Valsartan: Angiotensin II Receptor Blocker
Indications
- Hypertension
- Coronary Artery Disease
Common Dosage Forms
- Tablet
Typical Dosage
- Amlodipine 5 mg - Valsartan 160 mg to Amlodipine 10 mg - Valsartan 320 mg once daily
Pediatric Dosage
- Safety and efficacy not established in pediatric patients
Geriatric Dosage
- Dosage adjustment may be necessary due to age-related decline in renal function
Side Effects
- Dizziness
- Edema
- Flushing
- Headache
- Hypotension
- Palpitations
Contraindications
- Hypersensitivity to amlodipine, valsartan, or any component of the formulation
- Pregnancy (second and third trimesters)
Pregnancy Category
- Category D - Amlodipine
- Category D - Valsartan
Lactation Safety
- Lactation is not recommended due to potential risks
Drug Interactions
- Potassium-sparing diuretics may increase the risk of hyperkalemia when combined with valsartan
Overdose Symptoms
- Bradycardia
- Hypotension
- Shock
Antidote for Overdose
- Activated charcoal
- Symptomatic and supportive treatment
Storage Conditions
- Store at room temperature away from light and moisture
Pharmacokinetics
- Absorption: Amlodipine: Well absorbed after oral administration
- Distribution: Amlodipine: Extensively distributed; Valsartan: Highly bound to plasma proteins
- Metabolism: Amlodipine: Metabolized in the liver
- Excretion: Amlodipine: Eliminated in urine
Precautions
- Renal impairment
- Hepatic impairment
- Hypotension
- Hyperkalemia
Warnings
- Fetal toxicity may occur during pregnancy
Others
- Close monitoring of blood pressure and electrolytes is essential during therapy