Amlodipine Besilate + Atorvastatin
Generic Details
Generic Name
Amlodipine Besilate Atorvastatin
Other Names
- Amlodipine Atorvastatin
- Caduet
Drug Class
- Calcium Channel Blocker
- HMG-CoA Reductase Inhibitor
Chemical Formula
Molecular Weight
Mechanism of Action
- Amlodipine: Blocks the influx of calcium ions into vascular smooth muscle and cardiac muscle
- Atorvastatin: Inhibits HMG-CoA reductase, a rate-limiting enzyme in cholesterol biosynthesis
Indications
- Hypertension
- Coronary Artery Disease
- Dyslipidemia
Common Dosage Forms
- Tablet
Typical Dosage
- Amlodipine 5 mg - Atorvastatin 10 mg to Amlodipine 10 mg - Atorvastatin 80 mg once daily
Pediatric Dosage
Geriatric Dosage
Side Effects
- Edema
- Headache
- Flushing
- Muscle pain
- Abdominal pain
- Nausea
Contraindications
- Pregnancy
- Severe hepatic impairment
- Rhabdomyolysis
- Allergy to amlodipine or atorvastatin
Pregnancy Category
- X for Amlodipine
- X for Atorvastatin
Lactation Safety
- Amlodipine - Probably Unsafe
- Atorvastatin - Unsafe
Drug Interactions
- Statins
- Calcium Channel Blockers
- CYP3A4 Inhibitors
- Grapefruit juice
Overdose Symptoms
- Hypotension
- Bradycardia
- Shock
Antidote for Overdose
- Symptomatic and supportive treatment
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Amlodipine: Well absorbed after oral administration - Atorvastatin: Rapidly absorbed
- Distribution: Both drugs have large distributions volumes
- Metabolism: Amlodipine - Hepatic metabolism, Atorvastatin - Extensive hepatic metabolism
- Excretion: Both drugs and metabolites are primarily eliminated in the feces
Precautions
- Liver dysfunction
- Renal impairment
- Monitor liver function tests
- Avoid grapefruit juice
Warnings
- Risk of myopathy and rhabdomyolysis
- Increased risk of hypotension