Levosalbutamol (Oral)

Generic Details

Generic Name

Levosalbutamol Oral

Other Names

  • Levalbuterol Oral
  • Xopenex Oral

Drug Class

  • Beta2-Adrenergic Agonist

Chemical Formula

C25H37NO4

Molecular Weight

423.573 g/mol

Mechanism of Action

  • Selective beta2-adrenergic receptor agonist, resulting in smooth muscle relaxation in the airways.

Indications

  • Asthma
  • Chronic obstructive pulmonary disease (COPD)

Common Dosage Forms

  • Oral solution
  • Tablet

Typical Dosage

  • 2 mg, 3 times a day as needed for asthma exacerbations

Pediatric Dosage

  • Consult pediatrician for appropriate dosage

Geriatric Dosage

  • Adjust dosage based on renal function

Side Effects

  • Tremors
  • Nervousness
  • Headache
  • Palpitations
  • Muscle cramps

Contraindications

  • Hypersensitivity to levosalbutamol
  • Severe heart conditions

Pregnancy Category

  • Risk cannot be ruled out (Category C)

Lactation Safety

  • Considered safe but consult healthcare provider before use

Drug Interactions

  • Beta-blockers can antagonize effects
  • MAOIs may potentiate cardiovascular effects

Overdose Symptoms

  • Tachycardia
  • Tremors
  • Hyperactivity

Antidote for Overdose

  • Supportive care and symptom management

Storage Conditions

  • Store at room temperature away from moisture and heat

Pharmacokinetics

  • Absorption: Rapidly absorbed from the gastrointestinal tract
  • Distribution: Well-distributed in body tissues
  • Metabolism: Undergoes hepatic metabolism
  • Excretion: Excreted primarily in urine

Precautions

  • Monitor cardiac function during treatment
  • Use with caution in patients with diabetes or hyperthyroidism

Warnings

  • Do not exceed recommended dosage
  • Seek medical attention if symptoms worsen

Others

  • Levosalbutamol oral may be more expensive than its racemic form (albuterol) but has fewer side effects.