Amoxicillin Trihydrate
Generic Details
Generic Name
Amoxicillin-Trihydrate
Other Names
- Amoxil
- Moxatag
Drug Class
- Penicillin Antibiotic
Chemical Formula
C16H19N3O5S · 3H2O
Molecular Weight
419.45 g/mol
Mechanism of Action
- Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins
Indications
- Bacterial infections such as respiratory tract infections, urinary tract infections, skin infections, ear infections, and other bacterial infections
Common Dosage Forms
- Tablet
- Capsule
- Oral Suspension
Typical Dosage
- 250-500 mg every 8 hours for mild to moderate infections
- 875 mg every 12 hours for severe infections
Pediatric Dosage
- Dosing based on weight and severity of infection
Geriatric Dosage
- No adjustment necessary in mild to moderate renal impairment
Side Effects
- Diarrhea
- Nausea
- Vomiting
- Rash
- Hypersensitivity reactions
Contraindications
- Hypersensitivity to penicillins
- Infectious mononucleosis
- Severe renal impairment
Pregnancy Category
- Category B - Safe for use during pregnancy
Lactation Safety
- Safe to use while breastfeeding
Drug Interactions
- Probenecid - may increase amoxicillin levels in the body
Overdose Symptoms
- Nausea
- Vomiting
- Diarrhea
- Hyperactivity
Antidote for Overdose
- Supportive care and symptomatic treatment
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Rapidly and well absorbed after oral administration
- Distribution: Widely distributed in body tissues and fluids
- Metabolism: Partially metabolized in the liver
- Excretion: Excreted unchanged in the urine
Precautions
- Use with caution in patients with a history of allergic reactions to penicillins
Warnings
- Risk of severe and potentially fatal hypersensitivity reactions
Others
- Complete the full course of treatment even if feeling better to prevent antibiotic resistance