Lisinopril
Generic Details
Generic Name
Lisinopril
Other Names
- Prinivil
- Zestril
Drug Class
- Angiotensin-converting enzyme (ACE) inhibitor
Chemical Formula
C21H31N3O5
Molecular Weight
405.488 g/mol
Mechanism of Action
- Inhibition of ACE enzyme leading to vasodilation and reduced aldosterone secretion
Indications
- Hypertension
- Heart failure
- Acute myocardial infarction
- Diabetic nephropathy
Common Dosage Forms
- Tablet
Typical Dosage
- 10-40 mg once daily for hypertension
Pediatric Dosage
- Not established
Geriatric Dosage
- May require lower initial doses
Side Effects
- Cough
- Hypotension
- Hyperkalemia
- Dizziness
- Fatigue
Contraindications
- History of angioedema with ACE inhibitors
- Pregnancy
Pregnancy Category
- D
Lactation Safety
- Use with caution, considered compatible with breastfeeding
Drug Interactions
- Potassium-sparing diuretics
- NSAIDs
- Lithium
Overdose Symptoms
- Hypotension
- Electrolyte disturbances
Antidote for Overdose
- Fluid and electrolyte replacement
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Incomplete but rapid absorption after oral administration
- Distribution: Widely distributed in the body, crosses the placenta
- Metabolism: Partially metabolized in the liver
- Excretion: Primarily renal
Precautions
- Renal impairment
- Hyperkalemia
- Volume depletion
Warnings
- Risk of angioedema
- Hypotension