Lomefloxacin

Generic Details

Generic Name

Lomefloxacin

Other Names

    Drug Class

    • Fluoroquinolone Antibiotic

    Chemical Formula

    C17H19FN4O3

    Molecular Weight

    346.36 g/mol

    Mechanism of Action

    • Inhibition of bacterial DNA gyrase

    Indications

    • Treatment of bacterial infections such as urinary tract infections, respiratory tract infections, skin and soft tissue infections

    Common Dosage Forms

    • Tablet

    Typical Dosage

    • 400 mg once a day for 7-14 days for most infections

    Pediatric Dosage

    • Safety and efficacy not established in children under 18 years

    Geriatric Dosage

    • Dose adjustment may be needed based on renal function

    Side Effects

    • Common: Nausea, diarrhea, dizziness, headache
    • Serious: Tendon rupture, central nervous system effects, allergic reactions

    Contraindications

    • History of tendon disorders related to fluoroquinolone use

    Pregnancy Category

    • Category C - Risk can't be ruled out

    Lactation Safety

    • Use with caution, excretion in breast milk unknown

    Drug Interactions

    • Avoid concomitant use with multivitamins or mineral supplements containing iron, calcium, zinc, or magnesium as they can reduce absorption

    Overdose Symptoms

    • Nausea, vomiting, tremors, seizures

    Antidote for Overdose

    • No specific antidote, symptomatic and supportive treatment

    Storage Conditions

    • Store at room temperature away from moisture and heat

    Pharmacokinetics

    • Absorption: Well absorbed orally
    • Distribution: Widely distributed in body tissues
    • Metabolism: Metabolized in the liver
    • Excretion: Primarily excreted unchanged in the urine

    Precautions

    • Avoid in patients with a history of seizures or psychiatric disorders

    Warnings

    • Increased risk of tendinitis and tendon rupture, especially in elderly patients

    Others