Loratadine
Generic Details
Generic Name
Loratadine
Other Names
- Claritin
- Alavert
Drug Class
- Antihistamine
Chemical Formula
C22H23ClN2O2
Molecular Weight
382.88 g/mol
Mechanism of Action
- Competitive histamine H1-receptor antagonist
Indications
- Allergic rhinitis
- Chronic idiopathic urticaria
Common Dosage Forms
- Tablet
- Oral solution
- Orally disintegrating tablet
Typical Dosage
- 10 mg once daily
Pediatric Dosage
- 2-5 years: 5 mg once daily
- 6-12 years: 10 mg once daily
Geriatric Dosage
- Use with caution and individualize dosing based on renal function
Side Effects
- Headache
- Drowsiness
- Fatigue
- Dry mouth
Contraindications
- Hypersensitivity to loratadine or other antihistamines
Pregnancy Category
- Category B
Lactation Safety
- Limited data available, use caution
Drug Interactions
- Avoid concomitant use with strong CYP3A4 inhibitors
Overdose Symptoms
- Drowsiness
- Headache
- Increased heart rate
Antidote for Overdose
- No specific antidote, supportive care
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed from the gastrointestinal tract
- Distribution: Protein binding approximately 97%
- Metabolism: Extensively metabolized in the liver to desloratadine
- Excretion: Primarily via urine (40-45%) and feces (40-45%)
Precautions
- Use with caution in severe renal impairment
- May cause drowsiness, avoid driving or operating machinery
Warnings
- Do not exceed recommended dosage
Others
- Onset of action within 1-3 hours