Loratadine + Pseudoephedrine
Generic Details
Generic Name
Loratadine-Pseudoephedrine
Other Names
- Claritin-D
- Claritin-D 12 Hour
- Claritin-D 24 Hour
Drug Class
- Antihistamine
- Decongestant
Chemical Formula
Molecular Weight
Mechanism of Action
- Loratadine is an antihistamine that reduces the effects of natural chemical histamine in the body.
- Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages.
Indications
- Allergic rhinitis
- Nasal congestion
- Sinus congestion
Common Dosage Forms
- Tablet
- Extended-release tablet
Typical Dosage
- 1 tablet every 12 or 24 hours, as directed by a healthcare provider
Pediatric Dosage
- Dosage may vary based on child's age and weight. Consult a pediatrician.
Geriatric Dosage
- Lower doses may be required due to potential decreased renal function in the elderly.
Side Effects
- Dizziness
- Headache
- Dry mouth
- Nausea
- Insomnia
- Increased heart rate
Contraindications
- Hypersensitivity to loratadine, pseudoephedrine, or other antihistamines/decongestants
Pregnancy Category
- Category C - Risk cannot be ruled out
Lactation Safety
- Loratadine is considered safe while pseudoephedrine may reduce milk production.
Drug Interactions
- Monoamine oxidase inhibitors (MAOIs)
- Beta-blockers
- Tricyclic antidepressants
Overdose Symptoms
- Restlessness
- Hallucinations
- Fast or uneven heart rate
Antidote for Overdose
- Activated charcoal
- Symptomatic treatment
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Rapidly absorbed from the gastrointestinal tract
- Distribution: Protein binding of loratadine is 97–99% and pseudoephedrine is 38–44%
- Metabolism: Hepatic metabolism
- Excretion: Primarily renal excretion
Precautions
- Avoid using with high blood pressure, severe heart diseases, glaucoma, thyroid problems
Warnings
- May cause drowsiness, do not operate heavy machinery while taking this medication
Others
- Avoid alcohol consumption while taking loratadine-pseudoephedrine