Loteprednol Etabonate + Tobramycin

Generic Details

Generic Name

Loteprednol-Etabonate-Tobramycin

Other Names

  • Lotemax

Drug Class

  • Corticosteroid
  • Aminoglycoside Antibiotic

Chemical Formula

Molecular Weight

Mechanism of Action

  • Loteprednol-Etabonate: Corticosteroid with anti-inflammatory properties.
  • Tobramycin: Aminoglycoside antibiotic that inhibits protein synthesis in bacteria.

Indications

  • Post-operative inflammation following ocular surgery

Common Dosage Forms

  • Eye drops
  • Ointment

Typical Dosage

  • Apply 1 to 2 drops of the eye suspension into the affected eye 4 times daily

Pediatric Dosage

  • To be determined by a healthcare provider

Geriatric Dosage

  • Dosage adjustment may be needed based on individual patient factors

Side Effects

  • Blurred vision
  • Eye irritation
  • Increased intraocular pressure
  • Superficial punctate keratitis

Contraindications

  • Hypersensitivity to any component of the product

Pregnancy Category

  • C

Lactation Safety

  • Use with caution

Drug Interactions

  • Concomitant use of other eye medications should be discussed with a healthcare provider

Overdose Symptoms

    Antidote for Overdose

      Storage Conditions

      • Store at room temperature between 15-25°C (59-77°F)

      Pharmacokinetics

      • Absorption: Loteprednol-Etabonate: Rapidly absorbed after ocular administration
      • Distribution: Tobramycin: Widely distributed in body tissues after systemic absorption
      • Metabolism: Loteprednol-Etabonate: Metabolized to inactive metabolites in the eye
      • Excretion: Tobramycin: Eliminated primarily by the kidneys

      Precautions

      • Monitor intraocular pressure during treatment

      Warnings

      • Prolonged use may result in glaucoma or cataracts

      Others

      • Do not touch the tip of the container to any surfaces to prevent contamination