Lubiprostone
Generic Details
Generic Name
Lubiprostone
Other Names
- Amitiza
Drug Class
- Chloride Channel Activator
Chemical Formula
C20H32F2O5
Molecular Weight
390.5 g/mol
Mechanism of Action
- Activates type 2 chloride channels in the gastrointestinal tract, leading to increased intestinal fluid secretion and motility
Indications
- Chronic idiopathic constipation
- Irritable bowel syndrome with constipation
Common Dosage Forms
- Oral capsule
Typical Dosage
- 24 mcg twice daily with food and water
Pediatric Dosage
- Safety and efficacy not established in children
Geriatric Dosage
- Dose adjustment may be required in elderly patients
Side Effects
- Nausea
- Diarrhea
- Abdominal pain
- Flatulence
- Headache
Contraindications
- Mechanical gastrointestinal obstruction
Pregnancy Category
- Category C
Lactation Safety
- Use caution; not recommended during breastfeeding
Drug Interactions
- CYP3A4 inhibitors (e.g. ketoconazole) may increase exposure to lubiprostone
Overdose Symptoms
- Nausea
- Diarrhea
Antidote for Overdose
- Symptomatic treatment
Storage Conditions
- Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F)
Pharmacokinetics
- Absorption: Poorly absorbed
- Distribution: Mostly confined to the gastrointestinal tract
- Metabolism: Metabolized in the stomach to active metabolite
- Excretion: Mainly in the feces
Precautions
- Monitor for severe diarrhea
- Use with caution in patients with renal impairment
Warnings
- May cause dehydration; ensure adequate fluid intake