Lynestrenol
Generic Details
Generic Name
Lynestrenol
Other Names
- Lyndiol
- Orgametril
- Minobutyrol
Drug Class
- Progestin
- Progestogen
Chemical Formula
C20H28O2
Molecular Weight
300.440 g/mol
Mechanism of Action
- Progestational
- Antiandrogenic
Indications
- Oral contraception
- Dysfunctional uterine bleeding
- Endometriosis
Common Dosage Forms
- Tablet
Typical Dosage
- 0.5-2.5 mg daily
Pediatric Dosage
- Not established
Geriatric Dosage
- Use with caution due to potential increased risk of side effects
Side Effects
- Nausea
- Headache
- Breast tenderness
- Mood changes
- Irregular vaginal bleeding
Contraindications
- Pregnancy
- Breastfeeding
- Liver dysfunction
- History of thromboembolic disorders
Pregnancy Category
- X - Contraindicated
Lactation Safety
- Not recommended, excreted in breast milk
Drug Interactions
- Barbiturates
- Rifampicin
- St. John's Wort - may decrease effectiveness
Overdose Symptoms
- Nausea
- Vomiting
- Vaginal bleeding
Antidote for Overdose
- Symptomatic and supportive treatment
Storage Conditions
- Store at room temperature in a tightly closed container
Pharmacokinetics
- Absorption: Rapidly and well absorbed from the gastrointestinal tract
- Distribution: Highly bound to plasma proteins
- Metabolism: Metabolized in the liver
- Excretion: Excreted in urine and feces
Precautions
- Monitor for signs of thromboembolic disorders
- Regularly check liver function tests
Warnings
- Increased risk of cardiovascular events
- Increased risk of liver disorders
Others
- May help in the treatment of endometriosis